VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an important target in antiangiogenic therapy. Instead, it has received little attention from the field. In this study, using different animal models and multiple types of vascular cells, we revealed that although VEGF-B i...

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Hauptverfasser: Zhang, Fan, Tang, Zhongshu, Hou, Xu, Lennartsson, Johan, Li, Yang, Koch, Alexander W., Scotney, Pierre, Lee, Chunsik, Arjunan, Pachiappan, Dong, Lijin, Kumar, Anil, Rissanen, Tuomas T., Wang, Bin, Nagai, Nobuo, Fons, Pierre, Fariss, Robert, Zhang, Yongqing, Wawrousek, Eric, Tansey, Ginger, Raber, James, Fong, Guo-Hua, Ding, Hao, Greenberg, David A., Becker, Kevin G., Herbert, Jean-Marc, Nash, Andrew, Yla-Herttuala, Seppo, Cao, Yihai, Watts, Ryan J., Li, Xuri
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669337/
https://ncbi.nlm.nih.gov/pubmed/19369214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813061106
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