The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells

The phosphopeptide P140 issued from the spliceosomal U1-70K snRNP protein is recognized by lupus CD4(+) T cells, transiently abolishes T cell reactivity to other spliceosomal peptides in P140-treated MRL/lpr mice, and ameliorates their clinical features. P140 modulates lupus patients' T cell re...

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Detalhes bibliográficos
Main Authors: Page, Nicolas, Schall, Nicolas, Strub, Jean-Marc, Quinternet, Marc, Chaloin, Olivier, Décossas, Marion, Cung, Manh Thong, Van Dorsselaer, Alain, Briand, Jean-Paul, Muller, Sylviane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669294/
https://ncbi.nlm.nih.gov/pubmed/19390596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005273
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