Caveolin-1–mediated Suppression of Cyclooxygenase-2 via a β-catenin-Tcf/Lef–dependent Transcriptional Mechanism Reduced Prostaglandin E(2) Production and Survivin Expression

Augmented expression of cyclooxygenase-2 (COX-2) and enhanced production of prostaglandin E(2) (PGE(2)) are associated with increased tumor cell survival and malignancy. Caveolin-1 is a scaffold protein that has been proposed to function as a tumor suppressor in human cancer cells, although mechanis...

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Autors principals: Rodriguez, Diego A., Tapia, Julio C., Fernandez, Jaime G., Torres, Vicente A., Muñoz, Nicolas, Galleguillos, Daniela, Leyton, Lisette, Quest, Andrew F. G.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669036/
https://ncbi.nlm.nih.gov/pubmed/19244345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-09-0939
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