Paradoxical effects of IFN-γ in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury

Interferon-γ (IFN-γ) inhibits graft-versus-host disease (GVHD) in lethally irradiated mice receiving allogeneic hematopoietic cell transplantation (allo-HCT) but promotes lethality in unirradiated and sublethally irradiated recipients. We investigated the role of IFN-γ in GVHD in sublethally irradia...

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Detalhes bibliográficos
Main Authors: Wang, Hui, Asavaroengchai, Wannee, Yong Yeap, Beow, Wang, Min-Guang, Wang, Shumei, Sykes, Megan, Yang, Yong-Guang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668848/
https://ncbi.nlm.nih.gov/pubmed/19211507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-168419
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