Polo-Like Kinase-1 Controls Aurora A Destruction by Activating APC/C-Cdh1

Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-βTrCP. Here, we show that Plk1 is also required for the timely destruction of its activator Aurora A in...

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Detalhes bibliográficos
Principais autores: van Leuken, Renske, Clijsters, Linda, van Zon, Wouter, Lim, Dan, Yao, XueBiao, Wolthuis, Rob M. F., Yaffe, Michael B., Medema, René H., van Vugt, Marcel A. T. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668763/
https://ncbi.nlm.nih.gov/pubmed/19390576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005282
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