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Polo-Like Kinase-1 Controls Aurora A Destruction by Activating APC/C-Cdh1
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-βTrCP. Here, we show that Plk1 is also required for the timely destruction of its activator Aurora A in...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668763/ https://ncbi.nlm.nih.gov/pubmed/19390576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005282 |
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