250K SNP array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies

Two types of acquired loss of heterozygosity are possible in cancer: deletions and copy-neutral uniparental disomy (UPD). Conventionally, copy number losses are identified using metaphase cytogenetics while detection of UPD is accomplished by microsatellite and copy number analysis and as such, is n...

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Autori principali: Dunbar, Andrew J., Gondek, Lukasz P., O’Keefe, Christine L., Makishima, Hideki, Rataul, Manjot S., Szpurka, Hadrian, Sekeres, Mikkael A., Wang, Xiao Fei, McDevitt, Michael A., Maciejewski, Jaroslaw P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668538/
https://ncbi.nlm.nih.gov/pubmed/19074904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2754
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