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Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis. SIRT1, a NAD(+)-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. Here we demonstrate that hepatic SIRT1 re...

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Hlavní autoři: Purushotham, Aparna, Schug, Thaddeus T., Xu, Qing, Surapureddi, Sailesh, Guo, Xiumei, Li, Xiaoling
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668535/
https://ncbi.nlm.nih.gov/pubmed/19356714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.02.006
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