Design of (Gd-DO3A)(n)-Polydiamidopropanoyl-Peptide Nucleic Acid-d(Cys-Ser-Lys-Cys) Magnetic Resonance Contrast Agents

We hypothesized that chelating Gd(III) to 1,4,7-tris(carboxymethylaza)cyclododecane-10-azaacetylamide (DO3A) on peptide nucleic acid (PNA) hybridization probes would provide a magnetic resonance genetic imaging agent capable of hybridization to a specific mRNA. Because of the low sensitivity of Gd(I...

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Autores principales: Amirkhanov, Nariman V., Dimitrov, Ivan, Opitz, Armin W., Zhang, Kaijun, Lackey, John P., Cardi, Christopher A., Lai, Song, Wagner, Norman J., Thakur, Mathew L., Wickstrom, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668199/
https://ncbi.nlm.nih.gov/pubmed/18680101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21059
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