A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects

Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130. We used 1273 subjects (mean age 68 years) from the InCHIANTI Italian cohort to study common variation in the IL-6r locus and associations with...

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Detalhes bibliográficos
Main Authors: Rafiq, S, Frayling, TM, Murray, A, Hurst, A, Stevens, K, Weedon, MN, Henley, W, Ferrucci, L, Bandinelli, S, Corsi, A-M, Guralnik, JM, Melzer, D
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668154/
https://ncbi.nlm.nih.gov/pubmed/17671508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gene.6364414
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