Genome-wide association studies: the good, the bad and the ugly

Por Frayling, TM
Publicado no Clin Med (Lond) (2014)

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects

Por Rafiq, S, Frayling, TM, Murray, A, Hurst, A, Stevens, K, Weedon, MN, Henley, W, Ferrucci, L, Bandinelli, S, Corsi, A-M, Guralnik, JM, Melzer, D
Publicado em 2007

Association analysis of 29,956 individuals confirms that a low frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

Por Yaghootkar, H, Stancáková, A, Freathy, RM, Vangipurapu, J, Weedon, MN, Xie, W, Wood, AR, Ferrannini, E, Mari, A, Ring, SM, Lawlor, DA, Davey, Smith G, Jørgensen, T, Hansen, T, Pedersen, O, Steinthorsdottir, V, Guðbjartsson, DF, Thorleifsson, G, Thorsteinsdottir, U, Stefansson, K, Hattersley, AT, Walker, M, Morris, AD, McCarthy, MI, Palmer, CNA, Laakso, M, Frayling, TM
Publicado no Diabetes (2015)