A Genome-wide Survey of the Prevalence and Evolutionary Forces Acting on Human Nonsense SNPs

Nonsense SNPs introduce premature termination codons into genes and can result in the absence of a gene product or in a truncated and potentially harmful protein, so they are often considered disadvantageous and are associated with disease susceptibility. As such, we might expect the disrupted allel...

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Autores principales: Yngvadottir, Bryndis, Xue, Yali, Searle, Steve, Hunt, Sarah, Delgado, Marcos, Morrison, Jonathan, Whittaker, Pamela, Deloukas, Panos, Tyler-Smith, Chris
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668024/
https://ncbi.nlm.nih.gov/pubmed/19200524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2009.01.008
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