A Short Nur77-derived Peptide Converts Bcl-2 from a Protector to a Killer

Bcl-2 can be converted into a pro-apoptotic molecule by nuclear receptor Nur77. However, the development of Bcl-2 converters as anti-cancer therapeutics has not been explored. Here we report the identification of a Nur77-derived Bcl-2 converting peptide with 9 amino acids (NuBCP-9) and its enantiome...

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Autors principals: Kolluri, Siva Kumar, Zhu, Xiuwen, Zhou, Xin, Lin, Bingzhen, Chen, Ya, Sun, Kai, Tian, Xuefei, Town, James, Cao, Xihua, Lin, Feng, Zhai, Dayong, Kitada, Shinichi, Luciano, Frederick, O#x02019;Donnell, Edmond, Cao, Yu, He, Feng, Lin, Jialing, Reed, John C., Satterthwait, Arnold C., Zhang, Xiao-kun
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667967/
https://ncbi.nlm.nih.gov/pubmed/18835031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.09.002
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