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Sigma-1 receptor knockout mice display a depressive-like phenotype

Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig...

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Hlavní autoři: Sabino, Valentina, Cottone, Pietro, Parylak, Sarah L., Steardo, Luca, Zorrilla, Eric P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667953/
https://ncbi.nlm.nih.gov/pubmed/19100292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2008.11.036
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