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Absence of Caspase-3 Protects Pancreatic β-Cells from c-Myc-induced Apoptosis without Leading to Tumor Formation
c-Myc is a powerful trigger of β-cell apoptosis, proliferation, and dedifferentiation in rodent islets in vivo. In a transgenic mouse model, c-Myc induction causes rapid β-cell apoptosis and overt diabetes. When suppression of apoptosis is achieved by overexpression of Bcl-x(L) in an inducible model...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Society for Biochemistry and Molecular Biology
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667780/ https://ncbi.nlm.nih.gov/pubmed/19213729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806960200 |
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