Absence of Caspase-3 Protects Pancreatic β-Cells from c-Myc-induced Apoptosis without Leading to Tumor Formation

c-Myc is a powerful trigger of β-cell apoptosis, proliferation, and dedifferentiation in rodent islets in vivo. In a transgenic mouse model, c-Myc induction causes rapid β-cell apoptosis and overt diabetes. When suppression of apoptosis is achieved by overexpression of Bcl-x(L) in an inducible model...

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Detalhes bibliográficos
Main Authors: Radziszewska, Anna, Schroer, Stephanie A., Choi, Diana, Tajmir, Panteha, Radulovich, Nikolina, Ho, James C., Wang, Linyuan, Liadis, Nicole, Hakem, Razqallah, Tsao, Ming-Sound, Penn, Linda Z., Evan, Gerard I., Woo, Minna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667780/
https://ncbi.nlm.nih.gov/pubmed/19213729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806960200
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