Characterization of a Selective Inhibitor of Inositol Hexakisphosphate Kinases: USE IN DEFINING BIOLOGICAL ROLES AND METABOLIC RELATIONSHIPS OF INOSITOL PYROPHOSPHATES

Inositol hexakisphosphate kinases (IP6Ks) phosphorylate inositol hexakisphosphate (InsP(6)) to yield 5-diphosphoinositol pentakisphosphate (5-[PP]-InsP(5) or InsP(7)). In this study, we report the characterization of a selective inhibitor, N(2)-(m-(trifluoromethy)lbenzyl) N(6)-(p-nitrobenzyl)purine...

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Main Authors: Padmanabhan, Usha, Dollins, D. Eric, Fridy, Peter C., York, John D., Downes, C. Peter
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Enzyme Catalysis and Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667744/
https://ncbi.nlm.nih.gov/pubmed/19208622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900752200
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