Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation

The relationship between sphingosine kinase (SPHK), cellular ceramide concentration and chemosensitivity was investigated in human colon cancer cell lines. Among nine colon cancer cell lines, SPHK1 and SPHK2 activity and protein expression was highest in RKO cells and lowest in HCT116 cells. A viabi...

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Hlavní autoři: Nemoto, Satoshi, Nakamura, Mitsuhiro, Osawa, Yosuke, Kono, Saki, Itoh, Yoshinori, Okano, Yukio, Murate, Takashi, Hara, Akira, Ueda, Hiroshi, Nozawa, Yoshinori, Banno, Yoshiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Molecular Basis of Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667729/
https://ncbi.nlm.nih.gov/pubmed/19240026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900735200
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