Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells.

To examine the roles of PLD (phospholipase D) in the regulation of the apoptotic process, PLD1 and PLD2 were stably overexpressed in S1P3-CHO cells [CHO (Chinese-hamster ovary) cells expressing the S1P (sphingosine 1-phosphate) receptor S1P3]. Treatment of S1P3-CHO cells with ActD (actinomycin D) in...

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Detalhes bibliográficos
Main Authors: Yamada, Momoko, Banno, Yoshiko, Takuwa, Yoh, Koda, Masahiro, Hara, Akira, Nozawa, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223985/
https://ncbi.nlm.nih.gov/pubmed/14640974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031398
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