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VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo
Von Hippel-Lindau (VHL) disease is caused by germline mutations in the VHL tumor suppressor gene, with Type 2B missense VHL mutations predisposing to renal cell carcinoma, hemangioblastoma, and pheochromocytoma. Type 2B mutant pVHL is predicted to be defective in hypoxia inducible factor (HIF)-α reg...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667565/ https://ncbi.nlm.nih.gov/pubmed/19252526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.12 |
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