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Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse
Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial (FALS), and ∼25% of FALS cases are caused by mutations in Cu/Zn superoxide dismutase type 1 (SOD1). Mutant (MT) SOD1 is thought to be pathogenic because it misfolds and aggregates. A number of transgenic mice have been gener...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667291/ https://ncbi.nlm.nih.gov/pubmed/19233858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp085 |
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