Rational development of high-affinity T-cell receptor-like antibodies

T-cell interaction with a target cell is a key event in the adaptive immune response and primarily driven by T-cell receptor (TCR) recognition of peptide-MHC (pMHC) complexes. TCR avidity for a given pMHC is determined by number of MHC molecules, availability of coreceptors, and TCR affinity for MHC...

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Detalhes bibliográficos
Main Authors: Stewart-Jones, Guillaume, Wadle, Andreas, Hombach, Anja, Shenderov, Eugene, Held, Gerhard, Fischer, Eliane, Kleber, Sascha, Nuber, Natko, Stenner-Liewen, Frank, Bauer, Stefan, McMichael, Andrew, Knuth, Alexander, Abken, Hinrich, Hombach, Andreas A., Cerundolo, Vincenzo, Jones, E. Yvonne, Renner, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667008/
https://ncbi.nlm.nih.gov/pubmed/19307587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901425106
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