MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

BACKGROUND: Continuous high global tuberculosis (TB) mortality rates and variable vaccine efficacy of Mycobacterium bovis Bacille Calmette-Guérin (BCG) motivate the search for better vaccine regimes. Relevant models are required to downselect the most promising vaccines entering clinical efficacy te...

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Autori principali: Verreck, Frank A. W., Vervenne, Richard A. W., Kondova, Ivanela, van Kralingen, Klaas W., Remarque, Edmond J., Braskamp, Gerco, van der Werff, Nicole M., Kersbergen, Ariena, Ottenhoff, Tom H. M., Heidt, Peter J., Gilbert, Sarah C., Gicquel, Brigitte, Hill, Adrian V. S., Martin, Carlos, McShane, Helen, Thomas, Alan W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666807/
https://ncbi.nlm.nih.gov/pubmed/19367339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005264
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