Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and disease

BACKGROUND: Chitinolytic enzymes play important roles in the pathophysiology of allergic airway responses in mouse models of asthma. Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) have chitinolytic activity, but relatively little is known about their expression in human asthma. OBJE...

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Hauptverfasser: Seibold, Max A., Donnelly, Samantha, Solon, Margaret, Innes, Anh, Woodruff, Prescott G., Boot, Rolf G., Burchard, Esteban González, Fahy, John V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666777/
https://ncbi.nlm.nih.gov/pubmed/18845328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2008.08.023
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