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Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells

BACKGROUND: The proteasome inhibitor bortezomib has shown impressive clinical activity alone and in combination with conventional and other novel agents for the treatment of multiple myeloma (MM) and some solid cancers. Although bortezomib is known to be a selective proteasome inhibitor, the downstr...

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Hlavní autoři: Du, Zhen-Xian, Zhang, Hai-Yan, Meng, Xin, Guan, Yifu, Wang, Hua-Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666756/
https://ncbi.nlm.nih.gov/pubmed/19216805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-56
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