Performance of random forest when SNPs are in linkage disequilibrium

BACKGROUND: Single nucleotide polymorphisms (SNPs) may be correlated due to linkage disequilibrium (LD). Association studies look for both direct and indirect associations with disease loci. In a Random Forest (RF) analysis, correlation between a true risk SNP and SNPs in LD may lead to diminished v...

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Detalhes bibliográficos
Main Authors: Meng, Yan A, Yu, Yi, Cupples, L Adrienne, Farrer, Lindsay A, Lunetta, Kathryn L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666661/
https://ncbi.nlm.nih.gov/pubmed/19265542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-78
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