Mechanistic Insights into the Hydrolysis and Synthesis of Ceramide by Neutral Ceramidase

Ceramidase (CDase; EC 3.5.1.23) hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. The crystal structures of neutral CDase from Pseudomonas aerugin...

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Detalhes bibliográficos
Main Authors: Inoue, Tsuyoshi, Okino, Nozomu, Kakuta, Yoshimitsu, Hijikata, Atsushi, Okano, Hiroyuki, Goda, Hatsumi M., Tani, Motohiro, Sueyoshi, Noriyuki, Kambayashi, Kouji, Matsumura, Hiroyoshi, Kai, Yasushi, Ito, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666609/
https://ncbi.nlm.nih.gov/pubmed/19088069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808232200
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