BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration

The retinal pigment epithelium is a primary site of pathology in age-related macular degeneration. Oxidative stress and senescence are both thought to be important mediators of macular degeneration pathogenesis. We demonstrate here that bone morphogenetic protein-4 is highly expressed in the retinal...

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Bibliografiske detaljer
Main Authors: Zhu, DanHong, Wu, Jian, Spee, Christine, Ryan, Stephen J., Hinton, David R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Molecular Basis of Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666605/
https://ncbi.nlm.nih.gov/pubmed/19158083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809393200
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