Comparing Pooled Peptides with Intact Protein for Accessing Cross-presentation Pathways for Protective CD8(+) and CD4(+) T Cells

To better understand the mechanisms of intracellular trafficking and presentation of exogenous peptides by antigen-presenting cells (APC), we compared the handling of overlapping 24-mer peptides from HIV Nef either mixed or covalently linked in tandem in one protein. Once internalized, peptides traf...

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Detalhes bibliográficos
Main Authors: Zhang, Hongwei, Hong, Hai, Li, Demin, Ma, Shiwu, Di, Ying, Stoten, Adam, Haig, Neil, Di Gleria, Katalin, Yu, Zhanru, Xu, Xiao-Ning, McMichael, Andrew, Jiang, Shisong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666570/
https://ncbi.nlm.nih.gov/pubmed/19193636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809456200
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