Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

Human neutrophil Siglec-9 is a lectin that recognizes sialic acids (Sias) via an amino-terminal V-set Ig domain and possesses tyrosine-based inhibitory motifs in its cytoplasmic tail. We hypothesized that Siglec-9 recognizes host Sias as “self,” including in cis interactions with Sias on the neutrop...

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Bibliographic Details
Main Authors: Carlin, Aaron F., Uchiyama, Satoshi, Chang, Yung-Chi, Lewis, Amanda L., Nizet, Victor, Varki, Ajit
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Phagocytes, Granulocytes, and Myelopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665898/
https://ncbi.nlm.nih.gov/pubmed/19196661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-187302
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