Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

Chromosomal translocations involving the Mixed Lineage Leukemia (MLL) gene produce chimeric proteins that cause abnormal expression of a subset of HOX genes and leukemia development. Here, we show that MLL normally regulates expression of mir-196b, a hematopoietic microRNA located within the HoxA cl...

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Autors principals: Popovic, Relja, Riesbeck, Laurie E., Velu, Chinavenmeni S., Chaubey, Aditya, Zhang, Jiwang, Achille, Nicholas J., Erfurth, Frank E., Eaton, Katherine, Lu, Jun, Grimes, H. Leighton, Chen, Jianjun, Rowley, Janet D., Zeleznik-Le, Nancy J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665896/
https://ncbi.nlm.nih.gov/pubmed/19188669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-154310
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