Functional restoration of HCV-specific CD8 T-cells by PD1 blockade is defined by PD1 expression and compartmentalization

BACKGROUND & AIMS: The immuno-inhibitory receptor Programmed Death-1 (PD-1) is upregulated on dysfunctional virus-specific CD8 T-cells during chronic viral infections and blockade of PD-1:PD-ligand (PD-L) interactions can restore their function. As hepatitis C virus (HCV) persists in the liver w...

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Main Authors: Nakamoto, Nobuhiro, Kaplan, David E., Coleclough, Jennifer, Li, Yun, Kaminski, Mary, Shaked, Abraham, Olthoff, Kim, Gostick, Emma, Price, David A., Freeman, Gordon J., Wherry, E. John, Chang, Kyong-Mi
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665722/
https://ncbi.nlm.nih.gov/pubmed/18549878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.02.033
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