Synaptotagmin 2 Couples Mucin Granule Exocytosis to Ca(2+) Signaling from Endoplasmic Reticulum

Synaptotagmin 2 (Syt2) functions as a low affinity, fast exocytic Ca(2+) sensor in neurons, where it is activated by Ca(2+) influx through voltage-gated channels. Targeted insertion of lacZ into the mouse syt2 locus reveals expression in mucin-secreting goblet cells of the airways. In these cells, r...

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Detalhes bibliográficos
Main Authors: Tuvim, Michael J., Mospan, Andrea Rossi, Burns, Kimberlie A., Chua, Michael, Mohler, Peter J., Melicoff, Ernestina, Adachi, Roberto, Ammar-Aouchiche, Zoulikha, Davis, C. William, Dickey, Burton F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665099/
https://ncbi.nlm.nih.gov/pubmed/19208631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807849200
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