ERp57 Does Not Require Interactions with Calnexin and Calreticulin to Promote Assembly of Class I Histocompatibility Molecules, and It Enhances Peptide Loading Independently of Its Redox Activity

ERp57 is a thiol oxidoreductase that catalyzes disulfide formation in heavy chains of class I histocompatibility molecules. It also forms a mixed disulfide with tapasin within the class I peptide loading complex, stabilizing the complex and promoting efficient binding of peptides to class I molecule...

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Detalhes bibliográficos
Main Authors: Zhang, Yinan, Kozlov, Guennadi, Pocanschi, Cosmin L., Brockmeier, Ulf, Ireland, Breanna S., Maattanen, Pekka, Howe, Chris, Elliott, Tim, Gehring, Kalle, Williams, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665070/
https://ncbi.nlm.nih.gov/pubmed/19196713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808356200
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