Human Cytosolic Hydroxysteroid Dehydrogenases of the Aldo-ketoreductase Superfamily Catalyze Reduction of Conjugated Steroids: IMPLICATIONS FOR PHASE I AND PHASE II STEROID HORMONE METABOLISM

Aldo-ketoreductase 1C (AKR1C) enzymes catalyze the NADPH-dependent reduction of ketosteroids to hydroxysteroids. They are Phase I metabolizing enzymes for natural and synthetic steroid hormones. They convert 5α-dihydrotestosterone (Dht, potent androgen) to 3α/β-androstanediols (inactive androgens) a...

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Hlavní autoři: Jin, Yi, Duan, Ling, Lee, Seon Hwa, Kloosterboer, Helenius J., Blair, Ian A., Penning, Trevor M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Enzyme Catalysis and Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665056/
https://ncbi.nlm.nih.gov/pubmed/19218247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809465200
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