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Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway
APE1/Ref-1 is an essential DNA repair/gene regulatory protein in mammals of which intracellular level significantly affects cellular sensitivity to genotoxicants. The APE1 functions are altered by phosphorylation and acetylation. We here report that APE1 is also modified by ubiquitination. APE1 ubiq...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664849/ https://ncbi.nlm.nih.gov/pubmed/19219073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.5 |
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