Persistent Inflammation Induces GluR2 Internalization via NMDA Receptor-Triggered PKC Activation in Dorsal Horn Neurons

Spinal cord GluR2-lacking AMPA receptors (AMPARs) contribute to nociceptive hypersensitivity in persistent pain, but the molecular mechanisms underlying this event are not completely understood. We report that complete Freund's adjuvant (CFA)-induced peripheral inflammation induces synaptic Glu...

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Autors principals: Park, Jang-Su, Voitenko, Nana, Petralia, Ronald S., Guan, Xiaowei, Xu, Ji-Tian, Steinberg, Jordan P., Takamiya, Kogo, Sotnik, Andrij, Kopach, Olga, Huganir, Richard L., Tao, Yuan-Xiang
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664544/
https://ncbi.nlm.nih.gov/pubmed/19279258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4514-08.2009
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