Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

Throughout molecular evolution, organisms create assorted chemicals in response to varying ecological niches. Catalytic landscapes underlie metabolic evolution, wherein mutational steps alter the biosynthetic properties of enzymes. We report the first systematic quantitative characterization of a ca...

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Main Authors: O’Maille, P.E., Malone, A., Dellas, N, Hess, B. A., Smentek, L., Sheehan, I., Greenhagen, B.T., Chappell, J., Manning, G., Noel, J.P.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664519/
https://ncbi.nlm.nih.gov/pubmed/18776889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.113
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