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Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin
One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions. We present a conceptual framework that explains how this requirement causes the probability that a particular amino acid mutation is fixed during ev...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664478/ https://ncbi.nlm.nih.gov/pubmed/19381264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000349 |
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