Transcorneal Permeation of L - and D - Aspartate Ester Prodrugs of Acyclovir: Delineation of Passive Diffusion versus Transporter Involvement

PURPOSE: The aim of this study was to evaluate the contribution of amino acid transporters in the transcorneal permeation of the aspartate (Asp) ester acyclovir (ACV) prodrug. METHODS: Physicochemical characterization, solubility and stability of acyclovir L-aspartate (L-Asp-ACV) and acyclovir D-asp...

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Detalhes bibliográficos
Main Authors: Majumdar, Soumyajit, Hingorani, Tushar, Srirangam, Ramesh, Gadepalli, Rama Sarma, Rimoldi, John M, Repka, Michael A
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664401/
https://ncbi.nlm.nih.gov/pubmed/18839288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9730-0
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