Chronic Lymphocytic Leukemia (CLL) Cells Genetically Modified to Express B7-1, ICAM-1, and LFA-3 Confer APC Capacity to T Cells from CLL Patients

In chronic lymphocytic leukemia (CLL), malignant B cells and nonmalignant T cells exhibit dysfunction. We previously demonstrated that infection of CLL cells with modified vaccinia Ankara (MVA) expressing the costimulatory molecules B7-1, ICAM-1, and LFA-3 (designated TRICOM) increased expression of...

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Main Authors: Litzinger, Mary T., Foon, Kenneth A., Sabzevari, Helen, Tsang, Kwong-Yok, Schlom, Jeffrey, Palena, Claudia
格式: Artigo
語言:Inglês
出版: 2008
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664396/
https://ncbi.nlm.nih.gov/pubmed/19009294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0611-5
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