High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients

BACKGROUND: A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA testing is cheap in populations with founder effect and therefore recommended for all patients with OC diagnosis. Recurrent mutations constitute the vast majority of BRCA def...

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Bibliografski detalji
Glavni autori: Suspitsin, Evgeny N, Sherina, Nathalia Yu, Ponomariova, Daria N, Sokolenko, Anna P, Iyevleva, Aglaya G, Gorodnova, Tatyana V, Zaitseva, Olga A, Yatsuk, Olga S, Togo, Alexandr V, Tkachenko, Nathalia N, Shiyanov, Grigory A, Lobeiko, Oksana S, Krylova, Nadezhda Yu, Matsko, Dmitry E, Maximov, Sergey Ya, Urmancheyeva, Adel F, Porhanova, Nathalia V, Imyanitov, Evgeny N
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664323/
https://ncbi.nlm.nih.gov/pubmed/19338682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-7-5
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