High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients

BACKGROUND: A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA testing is cheap in populations with founder effect and therefore recommended for all patients with OC diagnosis. Recurrent mutations constitute the vast majority of BRCA def...

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Autori principali: Suspitsin, Evgeny N, Sherina, Nathalia Yu, Ponomariova, Daria N, Sokolenko, Anna P, Iyevleva, Aglaya G, Gorodnova, Tatyana V, Zaitseva, Olga A, Yatsuk, Olga S, Togo, Alexandr V, Tkachenko, Nathalia N, Shiyanov, Grigory A, Lobeiko, Oksana S, Krylova, Nadezhda Yu, Matsko, Dmitry E, Maximov, Sergey Ya, Urmancheyeva, Adel F, Porhanova, Nathalia V, Imyanitov, Evgeny N
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664323/
https://ncbi.nlm.nih.gov/pubmed/19338682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-7-5
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