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Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice

The agouti-yellow (A(y)) deletion is the only genetic modifier known to suppress testicular germ cell tumor (TGCT) susceptibility in mice or humans. The A(y) mutation deletes Raly and Eif2s2, and induces the ectopic expression of agouti, all of which are potential TGCT-modifying mutations. Here we r...

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Bibliografiske detaljer
Main Authors: Heaney, Jason D., Michelson, Megan V., Youngren, Kirsten K., Lam, Man-Yee J., Nadeau, Joseph H.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664146/
https://ncbi.nlm.nih.gov/pubmed/19168544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp045
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