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Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice
The agouti-yellow (A(y)) deletion is the only genetic modifier known to suppress testicular germ cell tumor (TGCT) susceptibility in mice or humans. The A(y) mutation deletes Raly and Eif2s2, and induces the ectopic expression of agouti, all of which are potential TGCT-modifying mutations. Here we r...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664146/ https://ncbi.nlm.nih.gov/pubmed/19168544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp045 |
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