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Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice

The agouti-yellow (A(y)) deletion is the only genetic modifier known to suppress testicular germ cell tumor (TGCT) susceptibility in mice or humans. The A(y) mutation deletes Raly and Eif2s2, and induces the ectopic expression of agouti, all of which are potential TGCT-modifying mutations. Here we r...

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Detalhes bibliográficos
Main Authors: Heaney, Jason D., Michelson, Megan V., Youngren, Kirsten K., Lam, Man-Yee J., Nadeau, Joseph H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664146/
https://ncbi.nlm.nih.gov/pubmed/19168544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp045
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