The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

Defective genome maintenance mechanisms, involving DNA repair and cell-cycle checkpoint pathways, initiate genetic instability in many sporadic and hereditary cancers. The DNA damage effector Checkpoint kinase 1 (Chk1) is a critical component of DNA replication, intra-S phase, and G(2)/M phase check...

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Main Authors: Peddibhotla, Sirisha, Lam, Michael H., Gonzalez-Rimbau, Maria, Rosen, Jeffrey M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663996/
https://ncbi.nlm.nih.gov/pubmed/19289837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806671106
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