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Influence of Hydroxylamine Conformation on Stereocontrol in Pd-Catalyzed Isoxazolidine-Forming Reactions

Palladium-catalyzed carboamination reactions between N-Boc-O-(but-3-enyl)hydroxylamine derivatives and aryl or alkenyl bromides afford cis-3,5- and trans-4,5-disubstituted isoxazolidines in good yield with up to >20:1 dr. The diastereoselectivity observed in the formation of cis-3,5-disubstituted...

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Bibliografiske detaljer
Main Authors: Lemen, Georgia S., Giampietro, Natalie C., Hay, Michael B., Wolfe, John P.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663962/
https://ncbi.nlm.nih.gov/pubmed/19239234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo8027399
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