Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex

The pyruvate dehydrogenase multienzyme assembly (PDH) generates acetyl coenzyme A and reducing equivalents from pyruvate in a multiple-step process that is a nexus of central metabolism. We report crystal structures of the Geobacillus stearothermophilus PDH E1p subunit with ligands that mimic the pr...

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Hauptverfasser: Pei, Xue Yuan, Titman, Christopher M., Frank, René A.W., Leeper, Finian J., Luisi, Ben F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663715/
https://ncbi.nlm.nih.gov/pubmed/19081062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.10.009
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