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Labeling Internalizing Anti-Epidermal Growth Factor Receptor Variant III Monoclonal Antibody with (177)Lu: In Vitro Comparison of Acyclic and Macrocyclic Ligands
INTRODUCTION: The monoclonal antibody (mAb) L8A4, reactive with the epidermal growth factor receptor variant III (EGFRvIII), internalizes rapidly in glioma cells after receptor binding. Combining this tumor specific mAb with the low energy β-emitter (177)Lu would be an attractive approach for brain...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2663407/ https://ncbi.nlm.nih.gov/pubmed/19217523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2008.11.001 |
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