Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

BACKGROUND: Although it has been postulated for many years that depression is associated with loss of synapses, primarily in the hippocampus, and that antidepressants facilitate synapse growth, we still lack ultrastructural evidence that changes in depressive behavior are indeed correlated with stru...

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Main Authors: Hajszan, Tibor, Dow, Antonia, Warner-Schmidt, Jennifer L., Szigeti-Buck, Klara, Sallam, Nermin L., Parducz, Arpad, Leranth, Csaba, Duman, Ronald S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663388/
https://ncbi.nlm.nih.gov/pubmed/19006787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.09.031
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