Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

BACKGROUND: Although it has been postulated for many years that depression is associated with loss of synapses, primarily in the hippocampus, and that antidepressants facilitate synapse growth, we still lack ultrastructural evidence that changes in depressive behavior are indeed correlated with stru...

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Hlavní autoři: Hajszan, Tibor, Dow, Antonia, Warner-Schmidt, Jennifer L., Szigeti-Buck, Klara, Sallam, Nermin L., Parducz, Arpad, Leranth, Csaba, Duman, Ronald S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663388/
https://ncbi.nlm.nih.gov/pubmed/19006787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.09.031
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