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Attenuated Foot-and-Mouth Disease Virus RNA Carrying a Deletion in the 3′ Noncoding Region Can Elicit Immunity in Swine

We constructed foot-and-mouth disease virus (FMDV) mutants bearing independent deletions of the two stem-loop structures predicted in the 3′ noncoding region of viral RNA, SL1 and SL2, respectively. Deletion of SL2 was lethal for viral infectivity in cultured cells, while deletion of SL1 resulted in...

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主要な著者: Rodríguez Pulido, Miguel, Sobrino, Francisco, Borrego, Belén, Sáiz, Margarita
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663259/
https://ncbi.nlm.nih.gov/pubmed/19211755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01836-08
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