Gamma Interferon-Induced Interferon Regulatory Factor 1-Dependent Antiviral Response Inhibits Vaccinia Virus Replication in Mouse but Not Human Fibroblasts

Vaccinia virus (VACV) replicates in mouse and human fibroblasts with comparable kinetics and efficiency, yielding similar titers of infectious progeny. Here we demonstrate that gamma interferon (IFN-γ) but not IFN-α or IFN-β pretreatment of mouse fibroblasts prior to VACV infection induces a long-la...

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Bibliographic Details
Main Authors: Trilling, Mirko, Le, Vu Thuy Khanh, Zimmermann, Albert, Ludwig, Holger, Pfeffer, Klaus, Sutter, Gerd, Smith, Geoffrey L., Hengel, Hartmut
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663247/
https://ncbi.nlm.nih.gov/pubmed/19211768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02042-08
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