High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing Antibodies

Plasmodium falciparum–infected erythrocytes bind endothelial receptors to sequester in vascular beds, and binding to ICAM1 has been implicated in cerebral malaria. Binding to ICAM1 may be mediated by the variant surface antigen family PfEMP1: for example, 6 of 21 DBLβC2 domains from the IT4 strain P...

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Main Authors: Oleinikov, Andrew V., Amos, Emily, Frye, Isaac Tyler, Rossnagle, Eddie, Mutabingwa, Theonest K., Fried, Michal, Duffy, Patrick E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2009
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663049/
https://ncbi.nlm.nih.gov/pubmed/19381252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000386
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